N-acetylcysteine renoprotection in methotrexate induced nephrotoxicity and its effects on B-cell lymphoma
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Acute and Chronic Effects of N-acetylcysteine on Pentylenetetrazole-induced Seizure and Neuromuscular Coordination in Mice
Background: N-acetylcysteine (NAC) has been indicated against experimental seizures, but with relatively inconclusive results. This study was undertaken to evaluate whether NAC exerts a dose-dependent anticonvulsant effect and to determine NAC safe therapeutic dose range and its muscle-relaxant activity in both acute and chronic uses.Methods: Following intraperitoneal (i.p.) administration of N...
متن کاملcomparative nephroprotective effects of silymarin, n-acetylcysteine, and thymoquinone against carbon tetrachloride-induced nephrotoxicity in rats
conclusions in conclusion, we suggest that tq may be used as a prophylactic agent against nephrotoxicity, especially in instances of tubular injury. however, human-based studies are still needed. objectives in this study, we investigated the comparative nephroprotective effects of silymarin, n-acetylcysteine (nac), and thymoquinone (tq) in animal models (rats) in which we induced nephrotoxicity...
متن کاملUltrastructural evaluation of the effect of N-acetylcysteine on methotrexate nephrotoxicity in rats.
The aim of this study is to investigate the possible protective effect of N-Acetylcysteine (NAC) against the likely methotrexate (MTX) toxicity on the kidney using ultrastructural together with biochemical data. Moreover, the immunohistochemical detection of Ki67 nuclear antigen is to be evaluated. Fifteen male Wistar albino rats, weighing 240-290 g, were divided into three equal groups: Rats r...
متن کاملProtective effects of erythropoietin and N-acetylcysteine on methotrexate-induced lung injury in rats.
OBJECTIVE Methotrexate (MTX) is known to have deleterious side effects on lung tissue. We aimed to investigate the effects of erythropoietin (EPO) and N-acetyl-cysteine (NAC) on MTX-induced lung injury in rats. STUDY DESIGN Animal experiment. MATERIAL AND METHODS Twenty-six female Sprague-Dawley rats were divided into 4 groups. Sham group, 0.3 mL saline; MTX group, 5 mg/kg MTX; EPO group, 5...
متن کاملN-acetylcysteine attenuates cyclosporin-induced nephrotoxicity in rats.
BACKGROUND Cyclosporin (CsA) has played an important role in the improvement of solid-organ transplant patients and graft survival. However, nephrotoxicity due to CsA remains an important clinical challenge. The renal toxicity of CsA is attributed to reduced renal blood flow which leads to hypoxia reoxygenation injury accompanied by excessive generation of oxygen-derived free radicals (ODFR). N...
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ژورنال
عنوان ژورنال: Indian Journal of Medical and Paediatric Oncology
سال: 2015
ISSN: 0971-5851
DOI: 10.4103/0971-5851.171545